Exploring the Association Between Demographics, SLC30A8 Genotype, and Human Islet Content of Zinc, Cadmium, Copper, Iron, Manganese and Nickel.

doi:10.1038/s41598-017-00394-3

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Exploring the Association Between Demographics, SLC30A8 Genotype, and Human Islet Content of Zinc, Cadmium, Copper, Iron, Manganese and Nickel.

Scientific reports - 28 Mar 2017

Wong Winifred P, Allen Norrina B, Meyers Matthew S, Link Emma O, Zhang Xiaomin, MacRenaris Keith W, El Muayed Malek

Abstract excerpt

A widely prevalent single nucleotide polymorphism, rs13266634 in the SLC30A8 gene encoding the zinc transporter ZnT8, is associated with an increased risk for T2DM. ZnT8 is mostly expressed in pancreatic insulin-producing islets of Langerhans. The effect of this variant on the divalent metal profile in human islets is unknown. Additionally, essential and non-essential divalent metal content of human islets under...

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PMID: 28352089
DOI: 10.1038/s41598-017-00394-3
PMCID: PMC5428289

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