Article

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

2018-10-22

Abstract excerpt

A rare loss-of-function variant p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8) enriched in Western Finland protects against type 2 diabetes (T2D). We recruited relatives of the identified carriers and showed that protection was associated with better insulin secretion due to enhanced glucose responsiveness and proinsulin conversion, especially compared with individuals matched for the genotype of a c...

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Literature Corpus work: ed111943-d062-5ce9-9f08-cb290fbdcd08
DOI: 10.1101/436030

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