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Article

Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na+ channel dynamics in human neurons.

Molecular psychiatry - 1 Sept 2026

Cui Lei, Kurganov Erkin, Hawes Derek, Hornauer Philipp, Lin Raozhou, Wang Yining, Hierlemann Andreas, Sheng Morgan, Nehme Ralda, Pan Jen Q

Abstract excerpt

Schizophrenia is a highly heritable psychiatric disorder, yet the molecular mechanisms by which genetic risk contributes to disease pathophysiology remain largely unknown. In this study, we investigate the functional consequences of XPO7 loss of function (LoF) in human induced pluripotent stem cell (iPSC)-derived neurons, focusing on its role as a schizophrenia risk gene identified through recent large-scale...

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Source

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Identifiers

PMID: 41986745
DOI: 10.1038/s41380-026-03587-3
PMCID: PMC13441981

Genes

XPO7
SCN2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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