Article
Evaluating the evaluation of cancer driver genes.
Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2016
Tokheim Collin J, Papadopoulos Nickolas, Kinzler Kenneth W, Vogelstein Bert, Karchin Rachel
Abstract excerpt
Sequencing has identified millions of somatic mutations in human cancers, but distinguishing cancer driver genes remains a major challenge. Numerous methods have been developed to identify driver genes, but evaluation of the performance of these methods is hindered by the lack of a gold standard, that is, bona fide driver gene mutations. Here, we establish an evaluation framework that can be applied to driver...
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