Article
Leveraging pleiotropic association using sparse group variable selection in genomics data.
BMC medical research methodology - 7 Jan 2022
Sutton Matthew, Sugier Pierre-Emmanuel, Truong Therese, Liquet Benoit
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) have identified genetic variants associated with multiple complex diseases. We can leverage this phenomenon, known as pleiotropy, to integrate multiple data sources in a joint analysis. Often integrating additional information such as gene pathway knowledge can improve statistical efficiency and biological interpretation. In this article, we propose statistical...
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