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Article

Localization of the discontinuous immunodominant region recognized by human anti-thyroperoxidase autoantibodies in autoimmune thyroid diseases.

The Journal of biological chemistry - 14 Mar 2003

Bresson Damien, Cerutti Martine, Devauchelle Gérard, Pugnière Martine, Roquet Francoise, Bes Cédric, Bossard Carine, Chardès Thierry, Péraldi-Roux Sylvie

Abstract excerpt

The discontinuous immunodominant region (IDR) recognized by autoantibodies directed against the thyroperoxidase (TPO) molecule, a major autoantigen in autoimmune thyroid diseases, has not yet been completely localized. By using peptide phage-displayed technology, we identified three critical motifs, LXPEXD, QSYP, and EX(E/D)PPV, within selected mimotopes which interacted with the human recombinant anti-TPO...

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Source

Identifiers

PMID: 12501244
DOI: 10.1074/jbc.M211930200

Genes

TPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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