Article
Start codon variant in LAG3 is associated with decreased LAG-3 expression and increased risk of autoimmune thyroid disease.
Nature communications - 9 Jul 2024
Saevarsdottir Saedis, Bjarnadottir Kristbjörg, Markusson Thorsteinn, Berglund Jonas, Olafsdottir Thorunn A, Halldorsson Gisli H, Rutsdottir Gudrun, Gunnarsdottir Kristbjorg, Arnthorsson Asgeir Orn, Lund Sigrun H, Stefansdottir Lilja, Gudmundsson Julius, Johannesson Ari J, Sturluson Arni, Oddsson Asmundur, Halldorsson Bjarni, Ludviksson Björn R, Ferkingstad Egil, Ivarsdottir Erna V, Sveinbjornsson Gardar, Grondal Gerdur, Masson Gisli, Eldjarn Grimur Hjorleifsson, Thorisson Gudmundur A, Kristjansdottir Katla, Knowlton Kirk U, Moore Kristjan H S, Gudjonsson Sigurjon A, Rognvaldsson Solvi, Knight Stacey, Nadauld Lincoln D, Holm Hilma, Magnusson Olafur T, Sulem Patrick, Gudbjartsson Daniel F, Rafnar Thorunn, Thorleifsson Gudmar, Melsted Pall, Norddahl Gudmundur L, Jonsdottir Ingileif, Stefansson Kari
Abstract excerpt
Autoimmune thyroid disease (AITD) is a common autoimmune disease. In a GWAS meta-analysis of 110,945 cases and 1,084,290 controls, 290 sequence variants at 225 loci are associated with AITD. Of these variants, 115 are previously unreported. Multiomics analysis yields 235 candidate genes outside the MHC-region and the findings highlight the importance of genes involved in T-cell regulation. A rare 5'-UTR variant...
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