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Article

Estimating Fitness of Viral Quasispecies from Next-Generation Sequencing Data.

Current topics in microbiology and immunology - 1 Jan 2016

Seifert David, Beerenwinkel Niko

Abstract excerpt

The quasispecies model is ubiquitous in the study of viruses. While having lead to a number of insights that have stood the test of time, the quasispecies model has mostly been discussed in a theoretical fashion with little support of data. With next-generation sequencing (NGS), this situation is changing and a wealth of data can now be produced in a time- and cost-efficient manner. NGS can, after removal of...

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PMID: 26318139
DOI: 10.1007/82_2015_462

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