Phylodynamics beyond neutrality: The impact of incomplete purifying selection on viral phylogenies and inference

Abstract excerpt

Viral phylodynamics focuses on using sequence data to make inferences about the population dynamics of viral infectious diseases. These inferences commonly include estimation of the viral growth rate, the reproduction number, and the time of most recent common ancestor. With few exceptions, existing phylodynamic inference approaches assume that all observed and ancestral viral genetic variation is fitness-neutral....

Topics

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• Adaptation, Physiological
• Antigenic Variation
• Evolution, Molecular
• Genetic Variation
• Genome, Viral
• High-Throughput Nucleotide Sequencing
• Mutation Rate
• Viruses

Identifiers and source

Literature Corpus work

5de49b7e-342d-5d42-9ba6-8fca55e65fbe

DOI

10.1101/2024.08.28.610037