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Article

AMaLa: Analysis of Directed Evolution Experiments via Annealed Mutational Approximated Landscape.

International journal of molecular sciences - 9 Oct 2021

Sesta Luca, Uguzzoni Guido, Fernandez-de-Cossio-Diaz Jorge, Pagnani Andrea

Abstract excerpt

We present Annealed Mutational approximated Landscape (AMaLa), a new method to infer fitness landscapes from Directed Evolution experiments sequencing data. Such experiments typically start from a single wild-type sequence, which undergoes Darwinian in vitro evolution via multiple rounds of mutation and selection for a target phenotype. In the last years, Directed Evolution is emerging as a powerful instrument to...

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Identifiers

PMID: 34681569
DOI: 10.3390/ijms222010908
PMCID: PMC8535593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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