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Article

FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans.

Cell - 17 Jun 2005

Sherwood David R, Butler James A, Kramer James M, Sternberg Paul W

Abstract excerpt

Cell invasion through basement membranes is crucial during morphogenesis and cancer metastasis. Here, we genetically dissect this process during anchor-cell invasion into the vulval epithelium in C. elegans. We have identified the fos transcription factor ortholog fos-1 as a critical regulator of basement-membrane removal. In fos-1 mutants, the gonadal anchor cell extends cellular processes normally toward vulval...

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Identifiers

PMID: 15960981
DOI: 10.1016/j.cell.2005.03.031

Genes

FOS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans.PMID 15960981Read ↗

A developmental gene regulatory network for invasive differentiation of the <i>C. elegans</i> anchor cellSemantic proximity Read ↗

Anchor cell invasion into the vulval epithelium in C. elegans.Semantic proximity Read ↗

AFF-1, a FOS-1-regulated fusogen, mediates fusion of the anchor cell in C. elegans.Semantic proximity Read ↗

The <i>C. elegans</i> homolog of the <i>Evi1</i> proto-oncogene, <i>egl-43</i> , coordinates G1 cell cycle arrest with pro-invasive gene expression during anchor cell invasionSemantic proximity Read ↗

The SWI/SNF chromatin remodeling assemblies BAF and PBAF differentially regulate cell cycle exit and cellular invasion <i>in vivo</i>Semantic proximity Read ↗

Dynamic compartmentalization of the pro-invasive transcription factor NHR-67 reveals a role for Groucho in regulating a proliferative-invasive cellular switch in C. elegansSemantic proximity Read ↗

The anchor cell initiates dorsal lumen formation during C. elegans vulval tubulogenesis.Semantic proximity Read ↗

The SWI/SNF chromatin remodeling assemblies BAF and PBAF differentially regulate cell cycle exit and cellular invasion in vivo.Semantic proximity Read ↗

The C. elegans F-spondin family protein SPON-1 maintains cell adhesion in neural and non-neural tissues.Semantic proximity Read ↗

SPARC Promotes Cell Invasion In Vivo by Decreasing Type IV Collagen Levels in the Basement Membrane.Semantic proximity Read ↗

How does a cell anchor and invade an organ?Semantic proximity Read ↗

Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans.Semantic proximity Read ↗

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