Article

A Functional <i>FCGR2A</i> Haplotype Associated with Rheumatoid Arthritis Determines Circulating Soluble FcγRIIa Levels and Immune Complex Signalling

2026-08-17

Abstract excerpt

FcγRIIa, encoded by FCGR2A , is a widely expressed Fc receptor implicated in autoimmunity and infectious disease susceptibility. To fine-map the rheumatoid arthritis (RA) association at the complex FCGR locus, we combined gene-specific resequencing, genetic association studies in UK and Spanish European cohorts, functional genomics, structural biology, biophysical analyses, and cellular assays. We identified a c...

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Literature Corpus work: 49929da8-4a62-5617-b737-f0efecae6283
DOI: 10.64898/2026.08.16.26360492

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