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Article

Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network.

Genome medicine - 19 Jul 2016

Richard Arianne C, Peters James E, Lee James C, Vahedi Golnaz, Schäffer Alejandro A, Siegel Richard M, Lyons Paul A, Smith Kenneth G C

Abstract excerpt

BACKGROUND: Tumour necrosis factor (TNF) superfamily cytokines and their receptors regulate diverse immune system functions through a common set of signalling pathways. Genetic variants in and expression of individual TNF superfamily cytokines, receptors and signalling proteins have been associated with autoimmune and inflammatory diseases, but their interconnected biology has been largely unexplored. METHODS: We...

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Identifiers

PMID: 27435189
DOI: 10.1186/s13073-016-0329-5
PMCID: PMC4952362

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TNF

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