Article
Extensive compensatory cis-trans regulation in the evolution of mouse gene expression.
Genome research - 1 Dec 2012
Goncalves Angela, Leigh-Brown Sarah, Thybert David, Stefflova Klara, Turro Ernest, Flicek Paul, Brazma Alvis, Odom Duncan T, Marioni John C
Abstract excerpt
Gene expression levels are thought to diverge primarily via regulatory mutations in trans within species, and in cis between species. To test this hypothesis in mammals we used RNA-sequencing to measure gene expression divergence between C57BL/6J and CAST/EiJ mouse strains and allele-specific expression in their F1 progeny. We identified 535 genes with parent-of-origin specific expression patterns, although few...
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