Article
Identification and evolutionary analysis of novel exons and alternative splicing events using cross-species EST-to-genome comparisons in human, mouse and rat.
BMC bioinformatics - 15 Mar 2006
Chen Feng-Chi, Chen Chuang-Jong, Ho Jar-Yi, Chuang Trees-Juen
Abstract excerpt
BACKGROUND: Alternative splicing (AS) is important for evolution and major biological functions in complex organisms. However, the extent of AS in mammals other than human and mouse is largely unknown, making it difficult to study AS evolution in mammals and its biomedical implications. RESULTS: Here we describe a cross-species EST-to-genome comparison algorithm (ENACE) that can identify novel exons for...
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