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Article

Large B-cell Lymphomas of Immune-Privileged Sites Relapse via Parallel Clonal Evolution from a Common Progenitor B Cell.

Cancer research - 2 Jun 2023

Los-de Vries G Tjitske, Stathi Phylicia, Rutkens Ryanne, Hijmering Nathalie J, Luijks Jeroen A C W, Groenen Patricia J T A, de Jong Daphne, Ylstra Bauke, Roemer Margaretha G M

Abstract excerpt

Large B-cell lymphoma of immune-privileged sites (LBCL-IP) arise in immune sanctuaries including the testis and central nervous system (CNS). After initially reaching complete response, relapses occur in almost 50% of patients, typically at other immune-privileged sites. Resolution of the clonal relationships and evolutionary patterns of LBCL-IP is required to understand the unique clinical behavior. We collected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36971477
DOI: 10.1158/0008-5472.CAN-22-3814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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