Article
The polymorphism L412F in TLR3 inhibits autophagy and is a marker of severe COVID-19 in males.
Autophagy - 1 Jul 2022
Croci Susanna, Venneri Mary Anna, Mantovani Stefania, Fallerini Chiara, Benetti Elisa, Picchiotti Nicola, Campolo Federica, Imperatore Francesco, Palmieri Maria, Daga Sergio, Gabbi Chiara, Montagnani Francesca, Beligni Giada, Farias Ticiana D J, Carriero Miriam Lucia, Di Sarno Laura, Alaverdian Diana, Aslaksen Sigrid, Cubellis Maria Vittoria, Spiga Ottavia, Baldassarri Margherita, Fava Francesca, Norman Paul J, Frullanti Elisa, Isidori Andrea M, Amoroso Antonio, Mari Francesca, Furini Simone, Mondelli Mario U, Gen-Covid Multicenter Study, Chiariello Mario, Renieri Alessandra, Meloni Ilaria
Abstract excerpt
The polymorphism L412F in TLR3 has been associated with several infectious diseases. However, the mechanism underlying this association is still unexplored. Here, we show that the L412F polymorphism in TLR3 is a marker of severity in COVID-19. This association increases in the sub-cohort of males. Impaired macroautophagy/autophagy and reduced TNF/TNFα production was demonstrated in HEK293 cells transfected with...
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