No impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19.

doi:10.1080/2162402X.2020.1857112

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No impact of cancer and plague-relevant FPR1 polymorphisms on COVID-19.

Oncoimmunology - 8 Dec 2020

Petrazzuolo Adriana, Le Naour Julie, Vacchelli Erika, Gaussem Pascale, Ellouze Syrine, Jourdi Georges, Solary Eric, Fontenay Michaela, Smadja David M, Kroemer Guido

Abstract excerpt

Formyl peptide receptor 1 (FPR1) is a pattern-recognition receptor that detects bacterial as well as endogenous danger-associated molecular patterns to trigger innate immune responses by myeloid cells. A single nucleotide polymorphism, rs867228 (allelic frequency 19-20%), in the gene coding for FPR1 accelerates the manifestation of multiple carcinomas, likely due to reduced anticancer immunosurveillance secondary...

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PMID: 33344044
DOI: 10.1080/2162402X.2020.1857112
PMCID: PMC7734042

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