Article
A role for Toll-like receptor 3 variants in host susceptibility to enteroviral myocarditis and dilated cardiomyopathy.
The Journal of biological chemistry - 23 Jul 2010
Gorbea Carlos, Makar Kimberly A, Pauschinger Matthias, Pratt Gregory, Bersola Jeathrina L F, Varela Jacquelin, David Ryan M, Banks Lori, Huang Chien-Hua, Li Hua, Schultheiss Heinz-Peter, Towbin Jeffrey A, Vallejo Jesús G, Bowles Neil E
Abstract excerpt
The innate antiviral response is mediated, at least in part, by Toll-like receptors (TLRs). TLR3 signaling is activated in response to viral infection, and the absence of TLR3 in mice significantly increases mortality after infection with enteroviruses that cause myocarditis and/or dilated cardiomyopathy. We screened TLR3 in patients diagnosed with enteroviral myocarditis/cardiomyopathy and identified a rare...
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