Article

An Alzheimer’s disease patient-derived olfactory cell model identifies gene expression changes associated with cognition

2022-08-23

Abstract excerpt

An early symptom of Alzheimer’s disease (AD) is an impaired sense of smell, for which the molecular basis remains elusive. Here, we generated human olfactory neurosphere-derived (ONS) cells from people with AD and mild cognitive impairment (MCI), and performed global RNA sequencing to determine gene expression changes. ONS cells expressed markers of neuroglial differentiation, providing a unique cellular model to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4f014edb-0f6c-59ec-9235-5a84dc3cba61
DOI: 10.1101/2022.08.22.504884

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An Alzheimer’s disease patient-derived olfactory cell model identifies gene expression changes associated with cognitionDOI 10.1101/2022.08.22.504884Read

An Alzheimer’s Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with CognitionSemantic proximity Read

The Proteome Profile of Olfactory Ecto-Mesenchymal Stem Cells-Derived from Patients with Familial Alzheimer’s Disease Reveals New Insights for AD StudySemantic proximity Read

Disease specific alterations in the olfactory mucosa of patients with Alzheimer’s diseaseSemantic proximity Read

Gateway: patient olfactory neurons for large-scale discovery in neurodegenerative diseaseSemantic proximity Read

Identification of candidate genes associated with clinical onset of Alzheimer’s diseaseSemantic proximity Read

Cell type-specific potential pathogenic genes and functional pathways in Alzheimer’s DiseaseSemantic proximity Read

Multiple Transcriptomic Analyses Explore Potential Synaptic Biomarker Rabphilin-3A for Alzheimer's DiseaseSemantic proximity Read

Mesenchymal Stem Cells from Familial Alzheimer's Patients Express MicroRNA Differently.Semantic proximity Read

A human embryonic stem cell model of Aβ-dependent chronic progressive neurodegenerationSemantic proximity Read

Single-cell transcriptomic analysis of Alzheimer’s diseaseSemantic proximity Read

Signatures for Viral Infection and Inflammation in the Proximal Olfactory System in Familial Alzheimer’s DiseaseSemantic proximity Read

Alterations in Alzheimer’s Disease-Associated Gene Expression in Severe Obstructive Sleep Apnea PatientsSemantic proximity Read