Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural Analysis

1 May 2013

Abstract excerpt

The immunoglobulin new antigen receptors (IgNARs) are a class of Ig-like molecules of the shark immune system that exist as heavy chain-only homodimers and bind antigens by their single domain variable regions (V-NARs). Following shark immunization and/or in vitro selection, V-NARs can be generated as soluble, stable, and specific high affinity monomeric binding proteins of ∼12 kDa. We have previously isolated a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement system in diseases
Share to Glycosylation and Glycoproteins Research
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23632026
DOI: 10.1074/jbc.m112.435289

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural AnalysisPMID 23632026Read ↗

The influence of antibody humanization on shark variable domain (VNAR) binding site ensemblesSemantic proximity Read ↗

Ancient species offers contemporary therapeutics: an update on shark VNAR single domain antibody sequences, phage libraries and potential clinical applicationsSemantic proximity Read ↗

Shark New Antigen Receptor (IgNAR): Structure, Characteristics and Potential Biomedical ApplicationsSemantic proximity Read ↗

Shark Variable New Antigen Receptor (VNAR) Single Domain Antibody Fragments: Stability and Diagnostic ApplicationsSemantic proximity Read ↗

Dissection of the IgNAR V domain: molecular scanning and orthologue database mining define novel IgNAR hallmarks and affinity maturation mechanisms.Semantic proximity Read ↗

Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding.Semantic proximity Read ↗

Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography.Semantic proximity Read ↗

Bamboo Shark as a Small Animal Model for Single Domain Antibody ProductionSemantic proximity Read ↗

On the humanization of VHHs: Prospective case studies, experimental and computational characterization of structural determinants for functionalitySemantic proximity Read ↗

Natural recognition repertoire and the evolutionary emergence of the combinatorial immune systemSemantic proximity Read ↗

Humanization of the Shark VNAR Single Domain Antibody Using CDR GraftingSemantic proximity Read ↗

Construction and next-generation sequencing analysis of a large phage-displayed VNAR single-domain antibody library from six naïve nurse sharksSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.