Article
Pharmacogenomics polygenic risk score: Ready or not for prime time?
Clinical and translational science - 1 Aug 2024
Singh Sonal, Stocco Gabriele, Theken Katherine N, Dickson Alyson, Feng QiPing, Karnes Jason H, Mosley Jonathan D, El Rouby Nihal
Abstract excerpt
Pharmacogenomic Polygenic Risk Scores (PRS) have emerged as a tool to address the polygenic nature of pharmacogenetic phenotypes, increasing the potential to predict drug response. Most pharmacogenomic PRS have been extrapolated from disease-associated variants identified by genome wide association studies (GWAS), although some have begun to utilize genetic variants from pharmacogenomic GWAS. As pharmacogenomic...
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