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Article

Utilization of polygenic risk scores in drug development protocols.

Pharmacogenomics - 1 Jan 2025

Pressly Michelle A, Schuck Robert, Mummaneni Padmaja, Roman Youssef M, Pacanowski Michael

Abstract excerpt

The development of polygenic risk scores (PRSs), which make use of genetic testing to assess an individual's risk of developing certain diseases or conditions based on collective genetic variant information, can be applied in drug development to enrich clinical trials or predict response to treatment. From querying documents submitted to the Food & Drug Administration, the landscape of use of PRSs across time...

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Identifiers

PMID: 40200755
DOI: 10.1080/14622416.2025.2489916
PMCID: PMC12118405

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