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Article

The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ.

Biochemical and biophysical research communications - 15 Jan 2022

Kopylova Galina V, Berg Valentina Y, Kochurova Anastasia M, Matyushenko Alexander M, Bershitsky Sergey Y, Shchepkin Daniil V

Abstract excerpt

The molecular mechanisms of pathogenesis of atrial myopathy associated with hypertrophic (HCM) and dilated (DCM) mutations of sarcomeric proteins are still poorly understood. For this, one needs to investigate the effects of the mutations on actin-myosin interaction in the atria separately from ventricles. We compared the impact of the HCM and DCM mutations of tropomyosin (Tpm) on the calcium regulation of the...

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Identifiers

PMID: 34942531
DOI: 10.1016/j.bbrc.2021.12.051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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