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Article

Cardiomyopathy-associated mutations in tropomyosin differently affect actin-myosin interaction at single-molecule and ensemble levels.

Journal of muscle research and cell motility - 1 Dec 2019

Kopylova Galina V, Shchepkin Daniil V, Nabiev Salavat R, Matyushenko Alexander M, Koubassova Natalia A, Levitsky Dmitrii I, Bershitsky Sergey Y

Abstract excerpt

In the heart, mutations in the TPM1 gene encoding the α-isoform of tropomyosin lead, in particular, to the development of hypertrophic and dilated cardiomyopathies. We compared the effects of hypertrophic, D175N and E180G, and dilated, E40K and E54K, cardiomyopathy mutations in TPM1 gene on the properties of single actin-myosin interactions and the characteristics of the calcium regulation in an ensemble of...

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PMID: 31643006
DOI: 10.1007/s10974-019-09560-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Cardiomyopathy-associated mutations in tropomyosin differently affect actin-myosin interaction at single-molecule and ensemble levels.PMID 31643006Read ↗

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