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Article

Impact of Troponin in Cardiomyopathy Development Caused by Mutations in Tropomyosin.

International journal of molecular sciences - 11 Dec 2022

Nefedova Victoria V, Kopylova Galina V, Shchepkin Daniil V, Kochurova Anastasia M, Kechko Olga I, Borzova Vera A, Ryabkova Natalia S, Katrukha Ivan A, Mitkevich Vladimir A, Bershitsky Sergey Y, Levitsky Dmitrii I, Matyushenko Alexander M

Abstract excerpt

Tropomyosin (Tpm) mutations cause inherited cardiac diseases such as hypertrophic and dilated cardiomyopathies. We applied various approaches to investigate the role of cardiac troponin (Tn) and especially the troponin T (TnT) in the pathogenic effects of Tpm cardiomyopathy-associated mutations M8R, K15N, A277V, M281T, and I284V located in the overlap junction of neighboring Tpm dimers. Using co-sedimentation...

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Identifiers

PMID: 36555368
DOI: 10.3390/ijms232415723
PMCID: PMC9779223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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