Article
Structural and Functional Effects of Cardiomyopathy-Causing Mutations in the Troponin T-Binding Region of Cardiac Tropomyosin.
Biochemistry - 10 Jan 2017
Matyushenko Alexander M, Shchepkin Daniil V, Kopylova Galina V, Popruga Katerina E, Artemova Natalya V, Pivovarova Anastasia V, Bershitsky Sergey Y, Levitsky Dmitrii I
Abstract excerpt
Hypertrophic cardiomyopathy (HCM) is a severe heart disease caused by missense mutations in genes encoding sarcomeric proteins of cardiac muscle. Many of these mutations are identified in the gene encoding the cardiac isoform of tropomyosin (Tpm), an α-helical coiled-coil actin-binding protein that plays a key role in Ca2+-regulated contraction of cardiac muscle. We employed various methods to characterize...
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