Article
Effects of Cardiomyopathic Mutations on the Cytoplasmic Tropomyosin Isoform Tpm1.7.
Molecules (Basel, Switzerland) - 22 May 2026
Roman Svetlana G, Nabiev Salavat R, Kochurova Anastasia M, Kopylova Galina V, Antonets Julia Y, Kleymenov Sergey Y, Mikhaylova Valeriya V, Shchepkin Daniil V, Matyushenko Alexander M, Nefedova Victoria V
Abstract excerpt
Tropomyosins (Tpm) are the family of actin-binding proteins encoded by four genes in humans. Missense mutations in the TPM1 gene associated with cardiomyopathies have been studied in the sarcomeric isoform Tpm1.1. The cardiomyopathy-causing mutations E40K and E54K are located in exon 2b of the TPM1 gene and may be expressed in non-muscle cytoplasmic Tpm isoforms, including Tpm1.7, which is associated with early...
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