Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of Cardiomyopathic Mutations in Tropomyosin on Calcium Regulation of the Actin-Myosin Interaction in Skeletal Muscle.

Bulletin of experimental biology and medicine - 1 Nov 2016

Kopylova G V, Shchepkin D V, Borovkov D I, Matyushenko A M

Abstract excerpt

Tropomyosin plays an important role in the regulation of actin-myosin interaction in striated muscles. Mutations in the tropomyosin gene disrupt actin-myosin interaction and lead to myopathies and cardiomyopathies. Tropomyosin with mutations in the α-chain is expressed in both the myocardium and skeletal muscles. We studied the effect of mutations in the α-chain of tropomyosin related to hypertrophic (D175N and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Buffers
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myosins

Share to Rabbits

Share to Solutions

Share to Tropomyosin

Share to Troponin

Source

Identifiers

PMID: 27878731
DOI: 10.1007/s10517-016-3540-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of Cardiomyopathic Mutations in Tropomyosin on Calcium Regulation of the Actin-Myosin Interaction in Skeletal Muscle.PMID 27878731Read ↗

The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ.Semantic proximity Read ↗

Effects of Cardiomyopathic Mutations on the Cytoplasmic Tropomyosin Isoform Tpm1.7.Semantic proximity Read ↗

Effects of two hypertrophic cardiomyopathy mutations in alpha-tropomyosin, Asp175Asn and Glu180Gly, on Ca2+ regulation of thin filament motility.Semantic proximity Read ↗

The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy.Semantic proximity Read ↗

Novel Mutation Glu98Lys in Cardiac Tropomyosin Alters Its Structure and Impairs Myocardial Relaxation.Semantic proximity Read ↗

Cardiomyopathy-associated mutations in tropomyosin differently affect actin-myosin interaction at single-molecule and ensemble levels.Semantic proximity Read ↗

Several cardiomyopathy causing mutations on tropomyosin either destabilize the active state of actomyosin or alter the binding properties of tropomyosin.Semantic proximity Read ↗

Structural and Functional Effects of Cardiomyopathy-Causing Mutations in the Troponin T-Binding Region of Cardiac Tropomyosin.Semantic proximity Read ↗

Structure-function relationship of muscle thin filament regulatory proteins : tropomyosin and troponinSemantic proximity Read ↗

Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.Semantic proximity Read ↗

Impact of Troponin in Cardiomyopathy Development Caused by Mutations in Tropomyosin.Semantic proximity Read ↗

De Novo Asp219Val Mutation in Cardiac Tropomyosin Associated with Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.