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Article

[Abnormal tropomyosin function in ATPase cycle in hypertrophic and dilated cardiomyopathies].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova - 1 Jan 2013

Borovikov Iu S, Karpicheva O E, Rysev N A, Redwood C S

Abstract excerpt

Pathogenesis of most myopathies including inherited hypertrophic (HCM) and dilated (DCM) cardiomyopathies is based on modification of structural state of contractile proteins induced by point mutations, such as mutations in alpha-tropomyosin (TM). To understand the mechanism of abnormal function of contractile system of muscle fiber due to Glu180Gly, Asp175 or Glu40Lys, Glu54Lys mutations in alpha-TM associated...

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PMID: 23659058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[Abnormal tropomyosin function in ATPase cycle in hypertrophic and dilated cardiomyopathies].PMID 23659058Read ↗

Hypertrophic cardiomyopathy-causing Asp175asn and Glu180gly Tpm1 mutations shift tropomyosin strands further towards the open position during the ATPase cycle.Semantic proximity Read ↗

Dilated cardiomyopathy mutations in alpha-tropomyosin inhibit its movement during the ATPase cycle.Semantic proximity Read ↗

The effect of the Asp175Asn and Glu180Gly TPM1 mutations on actin-myosin interaction during the ATPase cycle.Semantic proximity Read ↗

The effects of the tropomyosin cardiomyopathy mutations on the calcium regulation of actin-myosin interaction in the atrium and ventricle differ.Semantic proximity Read ↗

Aberrant movement of β-tropomyosin associated with congenital myopathy causes defective response of myosin heads and actin during the ATPase cycle.Semantic proximity Read ↗

Myopathy-causing Q147P TPM2 mutation shifts tropomyosin strands further towards the open position and increases the proportion of strong-binding cross-bridges during the ATPase cycle.Semantic proximity Read ↗

The flexibility of two tropomyosin mutants, D175N and E180G, that cause hypertrophic cardiomyopathy.Semantic proximity Read ↗

Effect of Cardiomyopathic Mutations in Tropomyosin on Calcium Regulation of the Actin-Myosin Interaction in Skeletal Muscle.Semantic proximity Read ↗

Novel mutation in the alpha-tropomyosin gene and transition from hypertrophic to hypocontractile dilated cardiomyopathy.Semantic proximity Read ↗

Molecular Mechanisms of Deregulation of Muscle Contractility Caused by the R168H Mutation in TPM3 and Its Attenuation by Therapeutic Agents.Semantic proximity Read ↗

Molecular mechanisms of deregulation of the thin filament associated with the R167H and K168E substitutions in tropomyosin Tpm1.1.Semantic proximity Read ↗

Several cardiomyopathy causing mutations on tropomyosin either destabilize the active state of actomyosin or alter the binding properties of tropomyosin.Semantic proximity Read ↗

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