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Article

Hypertrophic cardiomyopathy-causing Asp175asn and Glu180gly Tpm1 mutations shift tropomyosin strands further towards the open position during the ATPase cycle.

Biochemical and biophysical research communications - 1 Apr 2011

Borovikov Yurii S, Rysev Nikita A, Karpicheva Olga E, Redwood Charles S

Abstract excerpt

To understand the molecular mechanism by which the hypertrophic cardiomyopathy-causing Asp175Asn and Glu180Gly mutations in α-tropomyosin alter contractile regulation, we labeled recombinant wild type and mutant α-tropomyosins with 5-iodoacetamide-fluorescein and incorporated them into the ghost muscle fibers. The orientation and mobility of the probe were studied by polarized fluorimetry at different stages of...

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Identifiers

PMID: 21376702
DOI: 10.1016/j.bbrc.2011.02.139

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