Article

Biallelic variants in LARS1 induce steatosis in developing zebrafish liver via enhanced autophagy

2023-09-22

Abstract excerpt

Acute liver failure is a life-threatening condition during infancy. Biallelic pathogenic variants in LARS1 cause infantile liver failure syndrome type 1 (ILFS1), which is characterized by acute hepatic failure in infants. LARS functions as a protein associated with mTORC1 and plays a crucial role in amino acid-triggered mTORC1 activation and autophagy regulation. A previous study demonstrated that larsb -knockou...

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Literature Corpus work: 32ffd50a-ad55-5b67-b237-1921f3f1e1c9
DOI: 10.1101/2023.09.21.558924

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