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Article

The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance

20 Feb 2019

Abstract excerpt

Notwithstanding the numerous drugs available for liver cancer, emerging evidence suggests that chemotherapeutic resistance is a significant issue. HGF and its receptor MET play critical roles in liver carcinogenesis and metastasis, mainly dependent on the activity of receptor tyrosine kinase. However, for unknown reasons, all HGF-MET kinase activity-targeted drugs have failed or have been suspended in clinical...

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PMID: 30786811
DOI: 10.1080/15548627.2019.1580105

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