Hepatocyte FAM210A deficiency disrupts mitochondrial function and triggers juvenile steatosis with compensatory repair in adulthood

Abstract excerpt

Abstract Mitochondrial dynamics are central to maintaining liver metabolic homeostasis, yet the mechanisms that safeguarding mitochondrial integrity during development and metabolic dysfunction remain poorly defined. Here, we identify Family with sequence similarity 210 member A (FAM210A) as a hepatocyte-enriched mitochondrial regulator essential for postnatal liver maturation. Hepatocyte-specific deletion of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Liver Disease Diagnosis and Treatment
• Share to Mitochondrial Function and Pathology
• Share to Organ Transplantation Techniques and Outcomes