Article
Emergence and transmission of arbovirus evolutionary intermediates with epidemic potential.
Cell host & microbe - 11 Jun 2014
Stapleford Kenneth A, Coffey Lark L, Lay Sreyrath, Bordería Antonio V, Duong Veasna, Isakov Ofer, Rozen-Gagnon Kathryn, Arias-Goeta Camilo, Blanc Hervé, Beaucourt Stéphanie, Haliloğlu Türkan, Schmitt Christine, Bonne Isabelle, Ben-Tal Nir, Shomron Noam, Failloux Anna-Bella, Buchy Philippe, Vignuzzi Marco
Abstract excerpt
The high replication and mutation rates of RNA viruses can result in the emergence of new epidemic variants. Thus, the ability to follow host-specific evolutionary trajectories of viruses is essential to predict and prevent epidemics. By studying the spatial and temporal evolution of chikungunya virus during natural transmission between mosquitoes and mammals, we have identified viral evolutionary intermediates...
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