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Article

Detection of tumor-derived cell-free DNA in cerebrospinal fluid using a clinically validated targeted sequencing panel for pediatric brain tumors.

Journal of neuro-oncology - 1 Jun 2024

Ronsley Rebecca, Karvonen Kristine A, Cole Bonnie, Paulson Vera, Stevens Jeff, Crotty Erin E, Hauptman Jason, Lee Amy, Stasi Shannon M, Lockwood Christina M, Leary Sarah E S

Abstract excerpt

PURPOSE: Clinical sequencing of tumor DNA is necessary to render an integrated diagnosis and select therapy for children with primary central nervous system (CNS) tumors, but neurosurgical biopsy is not without risk. In this study, we describe cell-free DNA (cfDNA) in blood and cerebrospinal fluid (CSF) as sources for "liquid biopsy" in pediatric brain tumors. METHODS: CSF samples were collected by lumbar...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38755519
DOI: 10.1007/s11060-024-04645-y
PMCID: PMC13440093

Genes

BRAF
KIAA1549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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