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Article

IDH Mutations in AML Patients; A higher Association with Intermediate Risk Cytogenetics.

Asian Pacific journal of cancer prevention : APJCP - 1 Mar 2020

ElNahass Yasser H, Badawy Ragia H, ElRefaey Fatma A, Nooh Hend A, Ibrahiem Dalia, Nader Heba A, Mahmoud Hossam K, ElMetnawy Wafaa H

Abstract excerpt

OBJECTIVE: IDH mutations diversely affect the prognosis of cyogenetically normal acute myeloid leukemia (CN-AML) adult patients. The aim of this study is to assess the frequency of IDH mutations and to evaluate its role in AML prognosis. METHODS: We have analyzed IDH1 and 2 mutations using High Resolution Melting curve analysis (HRM) in 70 denovo AML patients. RESULTS: The median age of AML patients is 40 years...

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Identifiers

PMID: 32212799
DOI: 10.31557/APJCP.2020.21.3.721
PMCID: PMC7437334

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