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Article

IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia and associated with NPM1 mutations and FAB-M2 subtype.

International journal of laboratory hematology - 1 Oct 2012

Chao H-Y, Jia Z-X, Chen T, Lu X-Z, Cen L, Xiao R, Jiang N-K, Ying J-H, Zhou M, Zhang R

Abstract excerpt

INTRODUCTION: Gene mutations play an important role in acute myeloid leukemia (AML) pathogenesis. Several genes have been identified in AML, such as FLT3, KIT, NPM1, and JAK2. This study investigated the frequency of novel mutations in IDH1 (amino acid R132) and IDH2 (R140 and R172) and analyzed...

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Source

Identifiers

PMID: 22494415
DOI: 10.1111/j.1751-553X.2012.01422.x

Genes

IDH2
NPM1
FLT3
IDH1
JAK2
KIT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22494415-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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IDH2 mutations are frequent in Chinese patients with acute myeloid leukemia and associated with NPM1 mutations and FAB-M2 subtype.PMID 22494415Read ↗

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