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Clonal hematopoiesis is associated with improved survival in patients with metastatic colorectal cancer from the FIRE-3 trial

21 Dec 2021

Abstract excerpt

Clonal hematopoiesis (CH), defined by the acquisition of somatic mutations in hematopoietic stem cells, occurs in 20% to 30% of individuals .60 years and most frequently affects epigenetic regulator genes (DNMT3A, TET2, and ASXL1). CH is associated with a higher overall mortality and an approximately 10-fold risk for the development of hematologic malignancies. Reduced overall survival (OS) in individuals with CH...

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PMID: 34932794
DOI: 10.1182/blood.2021014108

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