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Article

MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains.

Scientific reports - 20 Dec 2021

Akifuji Chiaki, Iwasaki Mio, Kawahara Yuka, Sakurai Chiho, Cheng Yu-Shen, Imai Takahiko, Nakagawa Masato

Abstract excerpt

Human induced pluripotent stem cells (hiPSCs) can differentiate into cells of the three germ layers and are promising cell sources for regenerative medicine therapies. However, current protocols generate hiPSCs with low efficiency, and the generated iPSCs have variable differentiation capacity among different clones. Our previous study reported that MYC proteins (c-MYC and MYCL) are essential for reprogramming...

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Identifiers

PMID: 34930932
DOI: 10.1038/s41598-021-03260-5
PMCID: PMC8688507

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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