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Article

TRIM6 interacts with c-Myc and maintains pluripotency of mouse embryonal stem cells

1 Jan 2012

Abstract excerpt

The proto-oncogene product Myc is a master regulator of cell proliferation through its specific binding to the E-box motif in genomic DNA. It has been reported that Myc has an important role in the proliferation and maintenance of the pluripotency of embryonic stem (ES) cells and that the transcriptional activity of Myc is regulated by several post-translational modifications, including ubiquitination. In this...

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PMID: 22328504
DOI: 10.1242/jcs.095273

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