Article
Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.
Cell stem cell - 6 Nov 2008
Ema Masatsugu, Mori Daisuke, Niwa Hitoshi, Hasegawa Yoshikazu, Yamanaka Yojiro, Hitoshi Seiji, Mimura Junsei, Kawabe Yoh-ichi, Hosoya Tomohiro, Morita Masanobu, Shimosato Daisuke, Uchida Kazuhiko, Suzuki Norio, Yanagisawa Jun, Sogawa Kazuhiro, Rossant Janet, Yamamoto Masayuki, Takahashi Satoru, Fujii-Kuriyama Yoshiaki
Abstract excerpt
The transcription factor Klf4 has demonstrated activity in the reprogramming of somatic cells to a pluripotent state, but the molecular mechanism of this process remains unknown. It is, therefore, of great interest to understand the functional role of Klf4 and related genes in ESC regulation. Here, we show that homozygous disruption of Klf5 results in the failure of ESC derivation from ICM cells and early...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.