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Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine mapping in the MHC and genome wide

5 Nov 2021

Abstract excerpt

Because transethnic analysis may facilitate prioritization of causal genetic variants, we performed a genome-wide association study (GWAS) of psoriasis in South Asians (SAS), consisting of 2,590 cases and 1,720 controls. Comparison with our existing European-origin (EUR) GWAS showed that effect sizes of known psoriasis signals were highly correlated in SAS and EUR (Spearman ρ = 0.78; p < 2 × 10−14). Transethnic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34927100
DOI: 10.1016/j.xhgg.2021.100069

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