Article
Psoriasis regression analysis of MHC loci identifies shared genetic variants with vitiligo.
PloS one - 1 Jan 2011
Zhu Kun-Ju, Lv Yong-Mei, Yin Xian-Yong, Wang Zai-Xing, Sun Liang-Dan, He Su-Min, Cheng Hui, Hu Da-Yan, Zhang Zheng, Li Yang, Zuo Xian-Bo, Zhou You-Wen, Yang Sen, Fan Xing, Zhang Xue-Jun, Zhang Feng-Yu
Abstract excerpt
Psoriasis is a common inflammatory skin disease with genetic components of both immune system and the epidermis. PSOR1 locus (6q21) has been strongly associated with psoriasis; however, it is difficult to identify additional independent association due to strong linkage disequilibrium in the MHC region. We performed stepwise regression analyses of more than 3,000 SNPs in the MHC region genotyped using Human...
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