A Genetic Variation of Lipopolysaccharide Binding Protein Affects the Inflammatory Response and Is Associated with Improved Outcome during Sepsis.

doi:10.4049/immunohorizons.2100095

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Article

A Genetic Variation of Lipopolysaccharide Binding Protein Affects the Inflammatory Response and Is Associated with Improved Outcome during Sepsis.

ImmunoHorizons - 17 Dec 2021

Kumpf Oliver, Gürtler Kathleen, Sur Saubashya, Parvin Monalisa, Zerbe Lena-Karoline, Eckert Jana K, Weber Alexander N R, Oh Djin-Ye, Lundvall Linn, Hamann Lutz, Schumann Ralf R

Abstract excerpt

LPS binding protein (LBP) is an important innate sensor of microbial cell wall structures. Frequent functionally relevant mutations exist and have been linked to influence susceptibility to and course of bacterial infections. We examined functional properties of a single nucleotide polymorphism resulting in an exchange of phenylalanine to leucine at position 436 of LBP (rs2232618) and compared the frequent...

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PMID: 34921059
DOI: 10.4049/immunohorizons.2100095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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