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Article

Assessing CSF ctDNA to Improve Diagnostic Accuracy and Therapeutic Monitoring in Breast Cancer Leptomeningeal Metastasis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2022

Fitzpatrick Amanda, Iravani Marjan, Mills Adam, Childs Lucy, Alaguthurai Thanussuyah, Clifford Angela, Garcia-Murillas Isaac, Van Laere Steven, Dirix Luc, Harries Mark, Okines Alicia, Turner Nicholas C, Haider Syed, Tutt Andrew N J, Isacke Clare M

Abstract excerpt

PURPOSE: Cerebrospinal fluid (CSF) cytology is the gold standard diagnostic test for breast cancer leptomeningeal metastasis (BCLM), but has impaired sensitivity, often necessitating repeated lumbar puncture to confirm or refute diagnosis. Further, there is no quantitative response tool to assess response or progression during BCLM treatment. EXPERIMENTAL DESIGN: Facing the challenge of working with small-volume...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34921020
DOI: 10.1158/1078-0432.CCR-21-3017
PMCID: PMC7612501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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