Article
Detection of Aneuploidy in Cerebrospinal Fluid from Patients with Breast Cancer Can Improve Diagnosis of Leptomeningeal Metastases.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2021
Angus Lindsay, Deger Teoman, Jager Agnes, Martens John W M, de Weerd Vanja, van Heuvel Irene, van den Bent Martin J, Sillevis Smitt Peter A E, Kros Johan M, Bindels Eric M J, Heitzer Ellen, Sleijfer Stefan, Jongen Joost L M, Wilting Saskia M
Abstract excerpt
PURPOSE: Detection of leptomeningeal metastasis is hampered by limited sensitivities of currently used techniques: MRI and cytology of cerebrospinal fluid (CSF). Detection of cell-free tumor DNA in CSF has been proposed as a tumor-specific candidate to detect leptomeningeal metastasis at an earlier stage. The aim of this study was to investigate mutation and aneuploidy status in CSF-derived cell-free DNA (cfDNA)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.