Article
Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.
Nature genetics - 25 Sept 2011
Prickett Todd D, Wei Xiaomu, Cardenas-Navia Isabel, Teer Jamie K, Lin Jimmy C, Walia Vijay, Gartner Jared, Jiang Jiji, Cherukuri Praveen F, Molinolo Alfredo, Davies Michael A, Gershenwald Jeffrey E, Stemke-Hale Katherine, Rosenberg Steven A, Margulies Elliott H, Samuels Yardena
Abstract excerpt
G protein-coupled receptors (GPCRs), the largest human gene family, are important regulators of signaling pathways. However, knowledge of their genetic alterations is limited. In this study, we used exon capture and massively parallel sequencing methods to analyze the mutational status of 734 GPCRs in melanoma. This investigation revealed that one family member, GRM3, was frequently mutated and that one of its...
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