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Article

Network-Based Coverage of Mutational Profiles Reveals Cancer Genes.

Cell systems - 27 Sept 2017

Hristov Borislav H, Singh Mona

Abstract excerpt

A central goal in cancer genomics is to identify the somatic alterations that underpin tumor initiation and progression. While commonly mutated cancer genes are readily identifiable, those that are rarely mutated across samples are difficult to distinguish from the large numbers of other infrequently mutated genes. We introduce a method, nCOP, that considers per-individual mutational profiles within the context...

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Identifiers

PMID: 28957656
DOI: 10.1016/j.cels.2017.09.003
PMCID: PMC5997485

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