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Article

Gab2 deficiency prevents Flt3-ITD driven acute myeloid leukemia in vivo.

Leukemia - 1 Apr 2022

Spohr Corinna, Poggio Teresa, Andrieux Geoffroy, Schönberger Katharina, Cabezas-Wallscheid Nina, Boerries Melanie, Halbach Sebastian, Illert Anna L, Brummer Tilman

Abstract excerpt

Internal tandem duplications (ITD) of the FMS-like tyrosine kinase 3 (FLT3) predict poor prognosis in acute myeloid leukemia (AML) and often co-exist with inactivating DNMT3A mutations. In vitro studies implicated Grb2-associated binder 2 (GAB2) as FLT3-ITD effector. Utilizing a Flt3-ITD knock-in, Dnmt3a haploinsufficient mouse model, we demonstrate that Gab2 is essential for the development of Flt3-ITD driven...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34903841
DOI: 10.1038/s41375-021-01490-0
PMCID: PMC8979819

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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